Abstract: Objective To analyze the effects of gender, age and dosage on serum concentrations of antipsychotics, and to provide a reference for clinical applications of drug concentration monitoring. Methods The clinical data of outpatients who received antidepressant treatment in 2023, such as gender, age, dosage, and serum drug concentrations, was collected before being analyzed statistically using SPSS 26.0 ResultsThe data on serum concentration monitoring was collected from a total of 2 055 patients, involving 11 antipsychotics. The rate of compliance with the recommended range for treatment was the highest with haloperidol (82.35%) and lowest with clozapine (14.41%). According to the multiple linear regression equation, gender, age and dosage could do nothing more than account for some of the changes in serum drug concentrations. Except for aripiprazole and quetiapine, the C/D value of antipsychotic drugs was higher among females than among males, but there was a statistically significant difference in the case of risperidone, that is, the steady-state trough concentration of female patients was higher at the same dosage as males. There was no significant correlation between age and the C/D value of antipsychotic drugs, and the difference was not statistically significant. Conclusion There is considerable difference between individuals using antipsychotics, and there are many factors that affect serum drug concentrations. Dosage, gender, and age may all cause fluctuations in serum drug concentrations that should be monitored more rigorously when antidepressants are used.

Key words: Antipsychotics, Risperidone, Blood Drug Concentration, Dose Ratio, Rational Drug Use