Abstract: Objective To explore the feature and regularity of adverse drug reactions (ADRs) in acquired immune deficiency syndrome (AIDS) patients, and to provide reference for clinical pharmcovigilance and rational drug use. Methods A retrospective analysis was performed on 186 AIDS patients with all ADR reports which were reported to the National Drug Adverse Reaction Monitoring System from January 2016 to December 2018. Results Among the 186 cases of adverse drug reactions, there were 169 males and 17 females, and the majority (26.34%) were patients aged from 31 to 40 years old. A total of 61 drugs were involved, anti-infective drugs had the highest drug composition ratio (81.72%), among which sulfonamides caused the most ADR cases (46.05%). Skin and local lesion were the major clinical manifestations (40.76%). Conclusion The occurrence of ADR in AIDS patients may be associated with age, classes of drugs, and the frequency of use. Communicate and feedback the regularity and characteristics of ADR, which is beneficial for the clinicians to strengthen their vigilance against ADR and optimize treatment.

Key words: acquired immune deficiency syndrome patients, adverse drug reaction, rational use of drugs.