Research Progress of Pharmacological Activity and Toxicity of 5-Hydroxymethylfurfural

Abstract

Abstract: Objective To understand and summarize the recent progress in the pharmacology and toxicology research of 5-hydroxymethylfurfural(5-HMF). Methods The author listed the common pharmacological effects and toxicity of 5-HMF, and collected and analyzed the existing research data which showed the research direction of 5-HMF at the present stage, then emphasized the necessity of 5-HMF content detection and limited control. Results 5-HMF has both pharmacological activity and toxicity, and is widely present in food and medicine, and ultimately whether it is harmful to the human body or not depends on the route of exposure, the dose and frequency of exposure, therefore, people should pay more attention to the toxicity of 5-HMF. Conclusion The safety evaluation of 5-HMF may provide guidance for the quality control and safe application of 5-HMF-containing foods and drugs.

Key words: 5-hydroxymethylfurfural (5-HMF), pharmacological activity, toxicity, research progress

CLC Number:

R965

LI En-can, HE Jiu-ming, JIN Hong-tao, LIN Ni. Research Progress of Pharmacological Activity and Toxicity of 5-Hydroxymethylfurfural[J]. Chinese Journal of Pharmacovigilance, 2018, 15(4): 210-215.

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