Research Progress in Analytical Methods of Allergenic Components in Injection

Abstract

Abstract: Injection has been frequently reported to cause anaphylaxis. Establishing sensitive, effective and practical analytical methods for safety evaluation and quality control of injection can help to improve the safety of injection in clinical applications. In this review, we summarize the main analytical techniques for the determination of allergenic components in injection, including liquid chromatography-mass spectrometry, cell membrance chromatography and enzyme-linked immunosorbent assays, and discuss the applications, limitations and trends of these analytical techniques, hoping to provide reference for the improvement of the safety of injections.

Key words: injection, allergenic components, analytical method, quality evaluation

CLC Number:

R917

ZANG Qing-ce, JIN Hong-tao, ABLIZ Zeper, HE Jiu-ming. Research Progress in Analytical Methods of Allergenic Components in Injection[J]. Chinese Journal of Pharmacovigilance, 2018, 15(4): 216-220.

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