Abstract: Objective To explore the clinical toxicity characteristics and risk factors of Sophora tonkinensis Gagnep, in order to offer literature basis for clinical safety medication. Methods The adverse reactions of Sophora tonkinensis Gagnep on literatures from January 1st, 1953 to April 1st, 2016 were summarized, and the toxicity characteristics and risk factors for clinical use were analyzed. Results Oral use of Sophora tonkinensis Gagnep causes multiple organ damage, the main damages are nervous system damage and digestive damage. And other damages are dysmetabolism, hepatobiliory system damage, visual impairment, respiratory system injury, disorder of motor nerve. The main risk factors of adverse reactions of Sophora tonkinensis Gagnep are toxicity, drug overdose, misuse of different varieties, improper compatibility, using out of the direction of doctor and preventing disease. Conclusion Toxicity of Sophora tonkinensis Gagnep should be paid attention to in the clinical use, so as to control the risk factors and prevent the happening of the adverse drug reaction.

Key words: Sophora tonkinensis Gagnep, adverse reactions, literature analysis