Abstract: Objective To study the characteristics and regularities of adverse drug reactions (ADR) induced by antineoplastic drugs and provide references for the clinical rational use of antineoplastic drugs. Methads 907 reports of ADR induced by antineoplastic drugs from 2011 to 2016 in our hospital were retrospectively analyzed in terms of patient’s general information, drug varieties, routes of administration, occurrence time, involved organs-systems, clinical manifestations, treatments and outcomes. Results There is no difference between male and female. ADR of antineoplastic drugs mainly (74.42%) occurred in patients aged 40 years above. Most (82.58%) cases happened in 0~7 days after medication. 8 classes of antineoplastic drugs were involved, among which cisplatin occupied the top. Drug combinations were the main use of anti-tumor drugs (90.86%). Cisplatin for injection, dorsey injection, paclitaxel injection were the top three of combinations. Intravenous dripping was the main route of administration (74.54%). The blood system was the most involving system, followed by the digestive system, skin and its accessories. Most patients were improved or cured after given the appropriate treatment (87.10%). Conclusion Intensive cares should be adopted to reduce the occurrence of ADR when antineoplastic drugs were applied. Processing of ADR timely could reduce the harm and improve the safety of drug use.

Key words: antineoplastic drug, adverse reaction, rational use of drug, monitoring, bone marrow suppression