Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (4): 230-234.

Previous Articles     Next Articles

Literature Analysis of 146 Cases of Adverse Drug Reactions Induced by Carbamazepine

PAN-Li, LI Su-hua, ZHANG Xiao-le   

  1. Zhongshan Hospital of Dalian University, Liaoning Dalian 116001,China
  • Received:2017-07-05 Revised:2017-07-05 Online:2017-04-20 Published:2017-07-05

Abstract: Objective Through investigating the characteristics and mechanism of adverse drug reactions (ADRs) induced by carbamazepine, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using “carbamazepine”, “adverse reaction” and “to” as key words to search and retrieve articles in the CNKI database. According to inclusion and exclusion criteria to analyze the literature. Results A total of 52 papers, 146 cases, 194 series of ADR were included. Systems and organs mainly involved in ADRs were skin and its appendages, neurological and psychiatric system damage, cardiovascular system damage, blood system damage, etc. The skin and appendages damage was the most common reported ADRs, including bullous epidermal necrolysis, exfoliative dermatitis, etc. It causes severe organ failure and even death. Conclusion It is important to pay attention to the ADR caused by carbamazepine, strengthen clinical rational use of drugs, in order to prevent ADR and ensure the safe drug use in clinic.

Key words: carbamazepine, adverse drug reaction, literature review

CLC Number: