Chinese Journal of Pharmacovigilance ›› 2017, Vol. 14 ›› Issue (4): 226-229.

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Literature Analysis of 71 Cases of Adverse Drug Reactions Induced by Hydroxyurea

DAI Ting, QIAN Xi-fen   

  1. Wuxi No.5 People’s Hospital, Jiangsu Wuxi 214005,China
  • Received:2017-07-05 Revised:2017-07-05 Online:2017-04-20 Published:2017-07-05

Abstract: Objective Through investigating the characteristics and mechanism of adverse drug reactions (ADRs) induced by carbamazepine, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using “Hydroxyurea”, “adverse reaction” and “to” as key words to search and retrieve articles in the CNKI,VIP and WanFang Data. According to inclusion and exclusion criteria to analyze the literature. Results A total of 44 papers, 71 cases, 79 series of ADR were included. Systems and organs mainly involved in ADRs were skin and its appendages, systemic damage and digestive system damage. The skin and appendages damage was the most commonly reported ADRs, and refractory skin ulcer accounted for the most. Conclusion It is important to pay attention to the ADR, caused by hydroxyurea, strengthen clinical rational use of drugs, in order to prevent ADR and ensure the safe drug use in clinic.

Key words: hydroxyurea, adverse drug reaction, literature review

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