Clinical Application and Potential Risk of Xylitol-containing Injections

Abstract

Abstract: Objective To investigate the potential risks of xylitol-containing injections so as to promote rational use of these products in clinical practice. Methods The valid data of xylitol-containing injections were retrieved from the national database of drug adverse reaction monitoring and literature at home and abroad, and the characteristics and potential risks were analyzed. Results Xylitol-containing injections were widely used as glucose substitutes in our country. Although there are strict restrictions in the indications for such products, off-label use is common, which may increase the incidence of adverse reactions in patients. Additionally, some of the xylitol-containing formulations are not restricted for use in diabetic patients, and substantial intake of xylitol may happen. Conclusion Xylitol-containing injections should be used in accordance with indications, meanwhile, the potential risk of excessive intake of xylitol must be concerned about.

Key words: xylitol, safety, adverse drug reaction

CLC Number:

XU Xian-xing, YANG Jing-wen, WU Gui-zhi, DONG Duo. Clinical Application and Potential Risk of Xylitol-containing Injections[J]. Chinese Journal of Pharmacovigilance, 2017, 14(11): 680-682.

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