Abstract: Objective To observe the antipyretic efficacy of Sanhuangxiexin decoction by processing compatibility and explore the mechanisms preliminarily. Methods The fever models were established by subcutaneous injection with dried yeast suspension. Aspirin was used as the positive control (0.1 g•kg^-1), and Sanhuangxiexin decoction was divided into three doses （1, 0.5, 0.25 g crude drug•kg^-1), which was intragastrically administrated. Firstly the basal body temperature was measured before administration, then a measurement of the fever temperature was carried out after 0.5, 1, 2, 4 h, which was expressed as ΔT. The blood was sampled to separate and collecte the serum, and the hypothalamus tissues were taken to prepare supernatant from rats after the experiment. Finally, Elisa method was used to test the content of PGE₂, cAMP, Cox-1, Cox-2 both in the serum and hypothalamus. Results All three doses of Sanhuangxiexin decoction could decrease the temperature and the content of PGE₂, cAMP, Cox-1, Cox-2 in serum and hypothalamus. Conclusion The formula 8 of Sanhuangxiexin decoction has obvious antipyretic effect, and its mechanisms maybe relate to inhibition of the release of centric febrile mediators such as PGE₂ and cAMP, etc.

Key words: processing compatibility, Sanhuangxiexin decoction, antipyretic, mechanism