Abstract: Objective To understand the progress of the clinical utilization status and safety of tetanus antitoxin (TAT), and to provide references for post-marketing safety evaluation. Methods Domestic and foreign literatures on the clinical application and safety of TAT were reviewed for further analysis and comparison. Results Now TAT has been mainly used for passive immunity and tetanus therapeutics in clinic. Intensive safety studies showed that higher false-positive rate of its skin test mainly related to patient’s physique, medicine factor, infusion operation factor, and so on. Its main adverse effects included anaphylactic shock, erum sickness, and other kinds of adverse reactions. Conclusion TAT is still the first choice against tetanus of trauma patients in China, the paper suggests that medical workers must put emphasis on anaphylaxis and close observation, along with our country should expeditiously enact a specific against tetanus guidelines and standards of Chinese style, and promoting rational drug use.

Key words: tetanus antitoxin, clinical application, security