Abstract: Objective To observe the clinical application and safety of oral oseltamivir in hospitalized patients in the real-world during the height of an influenza outbreak, and to make recommendations for clinical application. Methods During this multi-center and retrospective research, all the information was collected from patients from six hospitals in Hubei Province who had taken oseltamivir between January 1, 2017 and April 30, 2017. The data on these patients was analyzed with specific focus on demographic characteristics, medical information and adverse reactions (ADRs). Results A total of 1 327 cases were collected, about 32.71% of whom were children under 3. Oral oseltamivir was prescribed mainly by departments of pediatrics, respiratory diseases and infections. The mean time of medication was 3.97 days. Only 9 cases recorded ADRs(0.68%). Conclusion Oral oseltamivir is widely used in clinical practice, and it is relatively safe. However, its clinical application needs to be standardized in order to reduce or prevent ADRs and ensure the safety of drug use.

Key words: oral oseltamivir, real-world, clinical application, safety