Abstract: Objective To find out more about the clinical use of Shuganning injection in order to provide data for the safe and proper use of the drug. Methods Domestic and overseas literature about Shuganning injection that was published between 2011 and 2020 was analyzed retrospectively in terms of clinical applications, solvent selection, drug combination, adverse event reports and improper use. Results Shuganning injection was capable of anti-inflammation, liver protection, and comprehensive adjustment. It played a positive role in treating various hepatic diseases, but there were some risks, the major one of which was its allergic effect and irrational use. Conclusion It is recommended that drug manufacturers continue to research this product, modify instructions if necessary, and provide legal basis for clinical use of this drug. Health care authorities and medical institutions should make the principles of syndrome differentiation of TCM better-known to doctors of Western medicine. Clinicians should strictly follow instructions to minimize the harm caused by adverse reactions.

Key words: Shuganning injection, clinical application, safety, rational, progress