Abstract: Objective To avoid medication risk and ensure the safety and effectiveness of parenteral nutrition treatment, through checking the total parenteral nutrition prescriptions and intervening unreasonable prescriptions of surgical department. Methods At PIVAS (pharmacy intravenous admixture service), pharmacists audited parenteral nutrition prescriptions of 24 surgical departments from January to June 2014 and recorded the unreasonable prescriptions to classify and analyze. Results Based on the analysis of 4 012 unreasonable parenteral nutrition prescriptions in our hospital, the irrational factors involved in deficiency or excess of nutritional components, overproof electrolyte ion concentration, inappropriate use of special nutritional supplements, unreasonable glycolipid proportion, repeated use of nutritional components, and etc. Conclusion The audit and intervention on parenteral nutrition prescriptions by the pharmacists were critical to ensure the safe,effective and economical nutritional treatment.

Key words: total parenteral nutrition, prescription audit, irrational factors