Visual analysis of knowledge map of toxic Chinese medicine Changshan toxicity-effect transformation based the thought of “yin du wei neng”

doi:10.19803/j.1672-8629.20230778

Abstract

Abstract: Objective Based on the idea of “yin du wei neng”, the knowledge map of Dichroa alkali and its derivatives were analyzed to provide theoretical basis for its toxicity-effect transformation.. Methods The relevant literature was retrieved from the core set of CNKICNKI database and Web of Science database from 1 January 1993 to 18 October 2023, and CiteSpace, VOSviewer and Excel software were used to analyze the publication volume, author, publishing agency, country, citation frequency and keywords of Chinese and English literature. Results A total of 235 articles were included, including 137 Chinese and 98 English articles. A total of 18 countries have conducted relevant studies on Ausomine and Authanone, among which the most studied country is China, followed by Israel, the United States and Japan. The institution with the largest number of articles in Chinese is the Key Laboratory of Veterinary Drug Creation of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, with 11 articles, and the institution with the largest number of English articles is Volcani Institute of Agricultural Research with 17 articles. The top 10 cited Chinese and English literature mainly focuses on the pharmacological activity and synthesis of alcamine and acanthone. Conclusion The research on alcamine and its derivatives shows an upward trend, and the co-occurrence and clustering of Chinese and English keywords show that the pharmacological activity, toxicity and structural modification of alcamine and astillone are the current research hotspots. The in-depth study of Aytamine and its derived antimalarial mechanism, emetogenic mechanism and compatibility attenuation mechanism is the key research trend in the future.

Key words: febrifugine, halofuginone, pharmacological activity, toxicity, structural modification, bibliometrics, CiteSpace, VOSviewer

CLC Number:

R954
R994.11

MA Li’na, HU Xiaozhen, ZHENG Changhui, SUN Ying, ZHAO Xu, CAO Junling, XIAO Xiaohe. Visual analysis of knowledge map of toxic Chinese medicine Changshan toxicity-effect transformation based the thought of “yin du wei neng”[J]. Chinese Journal of Pharmacovigilance, 2024, 21(1): 25-32.

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