Abstract: ObjectiveTo observe the chronic toxicity and severity occurred after administration of Kangguzhizengsheng capsules in rats. MethodsWistar rats were randomly divided into 4 groups. Each group was given Kangguzhizengsheng capsule at dose of 0.6g/100 g, 0.3 g/100 g, 0.15 g/100 g daily for up to 13 weeks, respectively. Blank control group was given same bulk of distilled water. After the withdrawal of the drug for 4 weeks the rats' body weight, hematology, blood biochemistry analysis and organ coefficients were measured, and organ coefficient were measured and main organs were examined by pathological method. ResultsThe outer appearance and behavior, body weights, organ coefficients, the indexes of hematology and biochemistry analysis in rats of drug taking groups showed no significant difference from those of control group. Pathological examination discovered no obvious pathological changes related to drug toxicity and no delayed toxicity reaction after drug withdrawal. ConclusionKangguzhizengsheng capsules had no obvious toxicity in rats for long-term administration, and is safe to use with clinical dosage.

Key words: Kangguzhizengsheng capsules, rats, chronic toxicity