Abstract: Objective To probe into the status,characterstics and influencing factors of ADR cases induced by allopurinol, for providing a reference for clinical treatment. Methods Data were collected from domestic published literatures from "China Journal Full-text Database" before 2013, and 420 case reports of adverse drug reactions induced by allopurinol were analyzed retrospectively. Results Older male patients appear to be with a high rate. Organs involved mainly are skin and its appendages(42.33%), systemic damage(22.77%), hepatobiliary system damage(9.90%). Severe damages to the skin are erythema multiforme system eruption , exfoliative dermatitis and hypersensitivity syndrome. Conclusion Allopurinol should be used reasonably, and the monitoring of clinical use should be strengthened to ensure the safety of medication.

Key words: allopurinol, adverse drug reactions, literature analysis