Abstract: Objective To introduce the research development on the establishments of animal models with rheumatoid arthritis, and think about efficacy evaluation of TCM. Methods References in the last decades at home and abroad about RA model were collated, analyzed and summarized. Results and Conclusion The main RA model are AA, CIA and so on. We should select suitable animal model on the basis of TCM's characteristic to screen out medicine and to evaluate the efficacy of medicine, and combine closely the research of RA's animal model with clinical disease to ensure the stability and reliability of animal model. And then to offer methodological ensurance for TCM's pharmacological preclinical research and efficacy evaluation.

Key words: rheumatoid arthritis, animal model, research progress