Abstract: Objective To observe the long term toxicity reaction of rats given Ganoderma Lucidum granule continuously. Methods The rats were randomly assigned to the control and three experimental groups, n =14 per group, equal number of male and female. Rats of three experimental groups were given Ganoderma Lucidum granule(ig) at dose of 1.5g·kg^-1, 3.0g·kg^-1, 6.0g·kg^-1 for 26 weeks. The body weight, urine, hematology, plasma prothrombin time, blood biochemistry and ratio of viscera to body were measured at the end of experiment. At the same time, the major organs were examined by pathology. Results The Results showed that the abnormity induced by Ganoderma Lucidum granule were not found in all experimental groups, and the development of rats were normal. Compared with the control group, the urine, hematology, plasma prothrombin time, blood biochemistry and ratio of viscera to body of drug taking groups showed no significant toxicological difference. The pathological examination discovered no obvious pathological changes relating to drug toxicity. Conclusion Our study shows that there is not toxicity of Ganoderma Lucidum granule given to rats for long term, and it is safe to administrate Ganoderma Lucidum granule continuously.

Key words: Ganoderma Lucidum, long term toxicity, rat