Abstract: Objective To probe into irritation of rabbit skin induced by Huangzhu Xiaozhong Lotion so that evidence could be provided for clinical application of Huangzhu Xiaozhong Lotion. Methods Acute skin irritation,scraped skin irritation and dermal sensitivity test were performed on the healthy rabbits in order to observe the irritation on complete and scraped skin of rabbit. Results Huangzhu Xiaozhong Lotion showed no irritation to complete and scraped skin of rabbit. Conclusion Huangzhu Xiaozhong Lotion demonstrated no skin toxic reaction to rabbit and could be widely used in clinic.

Key words: Huangzhu Xiaozhong Lotion, rabbit, skin irritation experiment