Abstract: Objective To assess the efficacy and adverse reaction of diclofenac sodium patch combined with glucosamine sulfate in the treatment of primary osteoarthritis(OA). Methods 96 patients with primary OA were divided into two groups. The treatment group received diclorenac sodium patch and glucosamine sulfate. The control group received diclofenac sodium sustained -release tablets.4 weeks later, assessed the efficacy and adverse reactions. Results There were significant differences between treatment group and control group in total clinical assessment and patient pain assessment. The total efficiency of treatment group was better than control group. There were less adverse reactions in treatment group than control group. Conclusion Patients with primary OA receiving diclofenac sodium patch combined with glucosamine sulfate would get better efficacy and less adverse reactions. This way is worth promoting in clinic.

Key words: diclofenac sodium patch, glucosamine sulfate, diclofenac sodium sustained-release tablets, primary osteoarthritis, efficacy, observation