Abstract: Objective To analyze the reasons of hematuria and renal failure in clinical applications of clindamycin injection, to provide references for clinical rational drug use. Methods According to literature retrieval of domestic medical journals from 2005 to June 2011 about the renal toxicity cases induced by Clindamycin injection, to analyze the frequency, dosage, blood drug concentration, combination and related substances of clindamycin injection in clinical medication. Results Acute renal failure and hematuria occurred in 86 cases, accounting for 53.75% of 160 cases. We think that the high concentration of medication, fast dropping speed, combined use of drugs and related substances are the main factors for kidney toxicity. Conclusion Pay more attention to the rational use of Clindamycin. standardize the range and dose in clinical use, perfect the insert sheet and improve the quality specification.

Key words: Clindamycin injection, renal failure, hematuria, kidney toxicity