Abstract: Objective To provide evidence for clinical use of flurbiprofen axetil injection and to prevent liver and kidney damage. Methods A retrospective view of the process of diagnosis and treatment of one patient was analyzed, who was cured with flurbiprofen axetil injection after unicompartmental knee arthroplasty and then appeared acute hepatic and renal failure. The relevance evaluation of severe adverse reaction was carried according to the ADR criteria established by National ADR Monitoring Center. Results The liver and kidney functions of the patient were restored to normal after the patient was stopped the flurbiprofen axetil injection and treated with blood purification combined with hemoperfusion and some liver protection and anti-infection medicines. Conclusion This case reminds us that in the clinical application of flurbiprofen axetil injection, in addition to paying attention to adverse reactions such as gastrointestinal tract and skin allergies, we also need to pay close attention to changes in liver and kidney function. At the same time, be vigilant for the symptoms and signs that predict liver and kidney toxicity, so as to ensure that clinical medications are effective and safe.

Key words: flurbiprofen axetil, adverse drug reaction, liver failure, renal failure