Chinese Journal of Pharmacovigilance ›› 2012, Vol. 9 ›› Issue (9): 513-515.

• Orginal Article •     Next Articles

Study on the Protective Effect of Total Flavonoids from Garduus Crispus. L for Mice Liver Injury

CAI Wei1, GUO Feng-Xia2, 3   

  1. 1 Qinghai Center for ADR Monitoring, Qinghai Xining 810007, China;
    2 Life Science and Geographical Science College of Qinghai Normal University; Qinghai Xining 810008, China;
    3 Key Laboratory of Environment and Resources of Qinghai-Tibet Plateau under the National Education Ministry, Qinghai Xining 810008, China
  • Received:2012-03-26 Online:2012-09-10 Published:2015-08-07

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Abstract: ObjectiveTo research the protective effect of total flavonoids from Garduus Crispus. L for mice liver injury models caused by delayed hypersensitivity induced by SRBC. MethodsThis experiment used mice as experimental objects. The model was built by SRBC 1.0×108 ·0.1mL-1 ·10g-1 ip followed by SRBC 0.5×108 ·0.2μL-1 ·10g-1 liver puncture attack 5 days later. Using total flavonoids from Garduus Crispus. L ig as experimental drug, the viscera index, plasma ALT and AST levels as well as liver SOD activity and MDA content were determined at last. ResultsThe visceral index and plasma ALT and AST in model group were significantly higher than that in placebo group, showing the autoimmune liver damage test model was built successfully. The viscera index, plasma ALT and AST levels as well as liver SOD activity and MDA content in each treatment group were significantly superior to that in model control group (P <0.05). ConclusionTotal flavonoids from Garduus Crispus. L can effectively resist the mice liver damage caused by delayed hypersensitivity induced by SRBC.

Key words: total flavonoids from Garduus Crispus L., ALT, AST, SOD, MDA, BCG, LPS, SRBC