Abstract: Objective To explore the situation and rules of adverse drug reactions(ADRs) of cephalosporins． MethodsThe ADRs of 29 kinds cephalosporins from 1169 cases,reported in WANFANG date base during 1998 to 2010, were collected and analysis． ResultsThe first 3 place on the 29 kinds of ADRs induced by cephalosporins were ceftriaxone(19.16%)、cefoperazone(16.60%) and cefradin(11.29%)． ADRs of cephalosporins often occurred in pediatric and teenagers under 10 years(16.08%)． The main administration routes were through intravenous injection(88.37%)．The adverse effects involved 16 organs/systems, with the most frequent in systemicr eactions(35.67%), followed by CNS and PNS(19.76%)、blood occurred occasionaly(13.94)． The clinical manifestation of ADRs were anaphylactic shock(28.14%)、disulfiram like reactions (12.74%) and screening(8.04%)． The onset of ADRs was usually within 30 min after administration(37.30%)．The onset of anaphylatic shock was usually within 10 mins after administration(60.79%)． 53 cases(4.76%) died． ConclusionWe should pay more attention to the ADRs of cephalosporins, such as anaphylactic shock．Test of cephalosporins was necessity and importance．

Key words: Cephalosporins, adverse drug reaction, Literature analysis