Abstract: Objective To study the preparation of Runchang tablet and its effects on lubricating intestine and facilitating bowel movements. Methods Runchang tablet was made from Runchang pill by the means of Microencapsulation. and it was detected in terms of morphology,tablet weight variation and disintegration. Using the tests of intestine moisture、small intestine driving and bowel movements, the effects of Runchang tablet on the function of intestine of mouse was investigated, and its pharmacological action was discussed. Results Runchang tablet manifested faint yellow tablet and its test was in line with standards specified Chinese pharmacopeia(2010 edition). Runchang tablet(4g·kg-1) could obviously facilitate the intestine moisture、small intestine driving and bowel movements of mouse(P<0.01), and its pharmacological action was superior to that of Runchang pill(P<0.05). It(2g·kg-1)could enforce the intestine moisture and small intestine driving of mouse distinctly(P<0.01), and this action was also superior to that of Runchang pill(P<0.05), of course, it could apparently increase bowel movements of mouse, too(P<0.05). Conclusion The pharm-acological action of Runchang tablet is superior to that of Runchang pill. This shows that the preparation of Runchang tablet designed by this paper is correct, effectual, and controllable in quality.

Key words: microencapsulation, preparation, runchang tablet, quality evaluation, pharmacodynamics, lubricating intestine and facilating bowel movements