Abstract: Objective To investigate the adverse drug reactions of Bisoprolol. Methods 216 cases of 1-2 level of essential hypertension patient, everyone of them takes the Bisoprolol tablet 2.5mg orally in the morning everyday. Patients were followed up once a week. If blood pressure has not been lowered to 140/90 mmHg following within 2 weeks, dosages are increased by take turns till 5 mg, 7.5mg, 10 mg, until effective dose or 10mg dosage full 8 weeks. Results 61 cases appeared adverse drug reactions, the incidence is 28.24%. for daily oral administration of 2.5-5.0mg, adverse drug reactions occurred in 16 cases, accounting for 11.59%. for daily oral administration of 7.5-10.0mg of 45 cases of adverse drug reaction occurred, accounting for 57.69%. There was a significant difference between the two groups(T=7.41,P<0.001). Stop Bisoprolol incidence of orally, and both have also the extremely remarkable different(T=4.78,P<0.001). Conclusion Bisoprolol incidence rate of adverse drug reactions and discontinuation treatment due to adverse drug reactions are higher. And it mostly occurs in the cardiovascular system, but most were relatively mild and tolerable, or may adhere to drug treatment, or rapid recovery after drug withdrawal, indicating Bisoprolol of more security.

Key words: Bisoprolol, adverse drug reaction(ADR)