Abstract: Objective To study the protective effect of Semen Aesculi extracts(SAE) on gastric ulcer induced by aspirin in mice. Methods The gastric ulcer was induced by aspirin. SAE(3.5, 7, 14 mg/kg) were administered orally once daily for five consecutive days, or the SAE(7mg/kg) was administered orally before or after the administration of aspirin. The gastric mucosa was examined under a dissecting microscope. Results The level of gastric mucosal lesions was lower in mice treated by SAE(7 or 14 mg/kg)(P<0.05). Simultaneous SAE(7mg/kg) administration with aspirin treatment attenuated the level of gastric mucosal lesions. Conclusion Semen Aesculi extracts can protect the mice from gastric ulcer induced by aspirin.

Key words: aspirin, gastric ulcer, Semen Aesculi extracts