One Case of Acute Liver Failure in Children with Kawasaki Disease Induced by High-dose Aspirin

doi:10.19803/j.1672-8629.2021.10.21

Abstract

Abstract: Objective To improve the safety of clinical use of high-dose aspirin. Methods One case of severe liver failure in a child with Kawasaki disease after using high-dose aspirin was reported and analyzed in combination with domestic and foreign literature. Results The patient was likely to suffer from aspirin-induced liver injury, which is rare in clinical practice and mainly related to the dosage. Conclusion When children with Kawasaki disease need to use large doses of aspirin, the liver function and related digestive system reactions should be closely monitored. Blood concentration monitoring of aspirin should be popularized to prevent such adverse drug reactions such as severe liver injury.

Key words: aspirin, acute liver injury, adverse drug reaction

CLC Number:

R994.11

YU Mingli, LUO Ji, CHEN Yonggang, CHEN Jie, PENG Jiangli. One Case of Acute Liver Failure in Children with Kawasaki Disease Induced by High-dose Aspirin[J]. Chinese Journal of Pharmacovigilance, 2021, 18(10): 989-991.

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