Abstract: Objective The purpose of this study was to explore the side -effect seldomly of Quetiapine. Methods Analysis the side-effect of Quetiapine that come frome four kinds journal of psychiatory in near eleven years Results The side-effect of Quetiapine was related to ten system that include twenty-three kinds diseases. The new side-effect was found that is nervous damage jaundice legs oedema, retention of urine complusine systeoms etc. Conclusion The side-effect of Quetiapine was more then other but it was may be cured. The Quetiapine is safety.

Key words: quetiapine, rare, adverse reaction