Abstract: Objective To analyze one case of acne caused by aripiprazole in order to provide a reference for safe and rational medications. Methods A personalized treatment plan and tips about medication were provided for a patient with acne caused by aripiprazole. The clinical manifestations, mechanism of occurrence, adverse outcomes and priorities of treatment of acne were analyzed based on literature. Results This case was a patient with mood disorder. After treatment with aripiprazole, the patient’s mood improved significantly, but acne appeared. The adverse reactions caused by aripiprazole were determined through causal relationships. By adjusting the personalized medication plan, the patient’s condition became stable and the symptoms of acne improved. Conclusion The adverse drug reactions of acne caused by aripiprazole can lead to a patient’s feelings of physical inferiority and social barriers, thereby reducing medication compliance. During medication, the patient ought to be given better pharmaceutical care. Symptoms of acne can be eliminated or mitigated by adjusting the treatment regimen.

Key words: Aripiprazole, Acne, Adverse Drug Reactions, Mood Disorder, Pharmaceutical Care