Suicidal tendency and paresthesia induced by voriconazole: a case report

doi:10.19803/j.1672-8629.20220533

Abstract

Abstract: Objective To analyze the causes of suicidal tendency and paresthesia induced by voriconazole and review the related literature so as to provide reference for safe use of this drug. Methods The clinical data on one patient with both pulmonary infection and suicidal tendency accompanied by nociception and abnormal taste who was treated with voriconazole for injection was analyzed. By reviewing relevant literature at home and abroad, and based on the trough concentration of voriconazole, CYP2C19 genotype and related indicators, the causes of adverse reactions were analyzed. Results CYP2C19 genotype was of the fast metabolic type, and the trough concentration of voriconazole was 5.12 mg·L-1.The causes of suicidal tendency and paresthesia induced by voriconazole were related to liver function, inflammatory indicators and albumin status. Conclusion Serum concentrations and metabolic enzyme gene types should be detected as soon as possible in elderly patients using voriconazole. Liver function, inflammatory indicators and nutritional status should be closely monitored. Individualized administration regimens should be formulated immediately to prevent psycho-nervous system adverse reactions caused by voriconazole.

Key words: voriconazole, suicide tendency, nocieption, abnormal taste, adverse drug reaction, liver function, inflammatory indicators, albumin status

CLC Number:

R978
R994.11

HU Biyuan, WANG Jing, ZHENG Weiqi, HU Hongping, CHEN Yongwu. Suicidal tendency and paresthesia induced by voriconazole: a case report[J]. Chinese Journal of Pharmacovigilance, 2023, 20(4): 469-472.

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