Advances in multi-target intervention in vascular endothelial injury in metabolic syndrome by traditional Chinese medicine

doi:10.19803/j.1672-8629.20220256

Abstract

Abstract: Metabolic syndrome（MS）is a cluster of clinical syndromes of multiple metabolic disorders with complex pathogenesis. It can develop into atherosclerosis and serious cardio-cerebrovascular diseases if quick intervention is impossible. Vascular endothelial injury is an early predictor and the main pathological basis of MS. Western medicine focuses on hypoglycemic, lipid-lowering and hypotensive treatments, so many of these drugs have obvious contraindications, and drug interactions occur in combined medications, which is likely to aggravate adverse drug reactions. Under the guidance of holistic concepts and treatments based on syndrome differentiation theories, traditional Chinese medicine is characterized by multi-component and multiple-target properties, long-lasting efficacy and smaller side effects in the intervention of vascular endothelial injury of MS. This article summarizes the research progress in Chinese herbs in the treatment of vascular endothelial injury in order to provide data for the prevention and treatment of MS-related vascular endothelial injury by TCM.

Key words: metabolic syndrome, vascular endothelial injury, traditional Chinese medicine, multi-target, adverse drug reaction

CLC Number:

R994.11

XU Shuai, ZHANG Ling, ZHAO Yuqing, YANG Yidian, BIAN Haoyu, ZHANG Liping. Advances in multi-target intervention in vascular endothelial injury in metabolic syndrome by traditional Chinese medicine[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 353-359.

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