Eighty-four cases of adverse drug reactions caused by novel anti-tumor drugs

doi:10.19803/j.1672-8629.20220188

Abstract

Abstract: Objective To analyze the characteristics and regularity of adverse drug reactions (ADR) caused by novel anti-tumor drugs in Anhui Chest Hospital so as to provide reference for rational use of drugs. Methods A total of 84 cases of ADR of novel anti-tumor drugs reported by our hospital to the national ADR Monitoring System from January 1, 2020 to December 31, 2021 were collected. These ADR were analyzed in terms of types, age and diseases of patients, types of drugs used, organs and/or systems involved, main drugs and clinical manifestations of severe ADR. Results Most of these patients were middle-aged and elderly ones (≥45 years old). The organs and/or systems at the highest risk of ADR were the digestive system and the skin and its accessory system. 34.52% of the cases were serious ADR and there were 9 cases of off-label drug use. Conclusion Clinicians and pharmacists should be alert to ADR caused by novel anti-tumor drugs, and the course of medication should be rigorously monitored so as to provide data for clinical drug safety and re-evaluation of drugs after marketing.

Key words: adverse drug reaction, novel anti-tumor drugs, targeted medicine, immunocheckpoint inhibitor, pharmaceutical care

CLC Number:

R994.11

YANG Yan, ZHOU Dexi, WU Xinli, XUE Shuya, DING Haihua, ZHANG Quan, ZHANG Yunling. Eighty-four cases of adverse drug reactions caused by novel anti-tumor drugs[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 334-338.

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