Acute liver and kidney injury due to rhabdomyolysis induced by rosuvastatin calcium tablets combined with probucol tablets

doi:10.19803/j.1672-8629.2022.07.22

Abstract

Abstract: Objective To explore ways to treat rhabdomyolysis along with acute liver injury and acute kidney injury induced by rosuvastatin calcium and probucol. Methods The process of treating one case of rhabdomyolysis along with acute liver injury and acute kidney injury due to rosuvastatin calcium and probucol was analyzed based on literature review. The mechanism by which rosuvastatin calcium and probucol induced rhabdomyolysis complicated with acute liver injury and acute kidney injury was investigated. Results The patient was diagnosed with rhabdomyolysis along with acute liver injury and acute kidney injury 14 days after rosuvastatin calcium and probucol were used. These two drugs were withdrawn on the same day and the patient was given sufficient rehydration, dieresis and hemodialysis. The level of CK and indexes of the liver and kidney of the patient decreased gradually and returned to the previous level 34 days after drug withdrawal. Conclusion The use of rosuvastatin calcium and probucol should be discontinued immediately in case of rhabdomyolysis along with acute liver injury and acute kidney injury. The patient should be given active fluid rehydration and hemodialysis if it is necessary.

Key words: rosuvastatin calcium tablets, probucol tablets, rhabdomyolysis, acute liver injury and acute kidney injury, adverse drug reaction

CLC Number:

R994.11

CHEN Jing, CHENG Hua, LIU Xianjun. Acute liver and kidney injury due to rhabdomyolysis induced by rosuvastatin calcium tablets combined with probucol tablets[J]. Chinese Journal of Pharmacovigilance, 2022, 19(7): 792-794.

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