Abstract: Objective To study the influencing factors and treatments of drug-induced liver injury(DILI) in our hospital in recent years and to provide data for clinical drug selection and treatment. Methods The data on patients with DILI between January 1, 2013 and 2020 January 1, was collected and analyzed. Results The main types of drugs that induced DILI were anti-infective drugs, traditional Chinese medicine, anti-lipidemic drugs, anti-tumor drugs, antipyretic and analgesic drugs. DILI was most likely to occur within 4 weeks of medication (72 cases). The incidence of DILI was slightly higher in male patients (51.00%) than in female ones (49.00%), and the average age was (51.0±17.7). The incidence of DILI was the highest among patients aged 41 to 60 (38.00%). In terms of complications, 82 cases had preexisting diseases. There was no significant difference in the incidence of DILI between different genders, age groups or between people with or without preexisting diseases (P>0.05). After drug-induced liver injury, 72 cases stopped taking drugs, 23 cases continued to take drugs, and 3 cases decreased the dosage. Among the 91 cases treated with hepatoprotective drugs, cases 23 were cured, 45 cases improved, 14 cases not cured and 9 cases unknown. Conclusion The dominating drugs that cause DILI are anti-infective drugs, followed by traditional Chinese medicine. The prognosis of DILI is generally good, and the incidence is relatively high among middle-aged and elder people. In order to prevent and reduce the occurrence of DILI, clinicians should strengthen monitoring and take immediate measures.

Key words: drug-induced liver injury, influencing factor, treatment, hepatoprotective agent, adverse drug reaction