Efficacy and Safety of Batroxobin in the Treatment of Sudden Hearing Loss: a Meta-analysis

doi:10.19803/j.1672-8629.2021.10.16

Abstract

Abstract: Objective To systematically review the efficacy and safety of batroxobin in the treatment of sudden hearing loss in order to provide evidence-based data for clinical medication. Methods Such databases as Pubmed, Embase, Cochrane Library, ClinicalTrials.gov, CNKI, Wanfang data, and Weipu were searched for randomized controlled trials of sudden hearing loss, and related literature was searched for manually. The data was screened and retrieved according to the inclusion and exclusion criteria. The quality of the enrolled literature was assessed by the quality assessment standard from Cochrane Handbook 5.0, with the cure rate, effective rate and incidence of adverse reactions as evaluation indexes. Software of RevMan 5.0 was used for the meta-analysis and subgroup analysis. Results A total of 25 randomized controlled trials were enrolled, involving 2 458 patients. Meta-analysis results suggested that the therapeutic effect in the batroxobin group was better than in the control with statistically significant difference. Only 4 randomized controlled trials reported adverse reactions that manifested themselves as a decrease of fibrinogen, dizziness, nausea, purpura, and a mild increase of transaminase. Conclusion Meta-analysis results show that batroxobin can be used alone or in combination with other drugs for the treatment of sudden hearing loss. But whether it can be used as a first-line drug needs to be confirmed by more rigorous and scientific clinical trials.

Key words: batroxobin, sudden hearing loss, Meta-analysis, safety

CLC Number:

R969.3

GONG Li, SU Shuping, TIAN Xiaojiang, TANG Xuewen, JI Huanhuan, MENG Long, JIA Yuntao. Efficacy and Safety of Batroxobin in the Treatment of Sudden Hearing Loss: a Meta-analysis[J]. Chinese Journal of Pharmacovigilance, 2021, 18(10): 969-974.

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