Abstract: ObjectiveTo investigate the causes of and solutions to angioedema induced by acetylcysteine injection. Methods The possibility of and solutions to angioedema caused by acetylcysteine injection were analyzed in one patient with arteriosclerosis obliterans admitted to the Department of Vascular Surgery of the First Hospital of Jilin University in September 2018. Results A 65-year-old female patient was admitted to the hospital because her left lower limb had felt cold, numb and hurt for a year.On the first day after admission, the patient was intravenously given 8 g acetylcysteine along with 250 mL 5% glucose.After eighty minutes, such symptoms of angioedema appeared as facial edema and systemic rash.Medication was discontinued right away and antiallergic treatment was offered.The above symptoms disappeared after one hour of symptomatic treatment. On the 14th day, the patient got better and was discharged. Conclusion Acetylcysteine injection might have caused angioedema in this patient. Dripping has to be slow while this drug is injected, and it should be used with caution among patients with a history of drug allergy and asthma. At the same time, the patient has to be attended to and observed closely.

Key words: acetylcysteine, angioedema, adverse drug reactions