Abstract: Objective To explore the regularities and characteristics of adverse reactions induced by baclofen in patients with renal insufficiency so as to provide reference for rational clinical use of this drug. Methods The CNKI, VIP, Pubmed, Wiley and EBSCO database were searched to retrieve related articles published between 1990 and 2018 . The clinical data of baclofen induced adverse reactions in patients with renal diseases was collected and statistically analyzed. Results A total of thirty-one pieces of literature involving forty-eight cases were enrolled for analysis. The patients comprised twenty-eight males (58.33%) and twenty females (41.67%). Twenty-nine of them (61.70%) were above 60 and 43 of them (89.58%) were patients with ESRD. The adverse drug reactions induced by baclofen usually started within four days (77.08%). The daily dose of baclofen ranged from 5mg to 30mg. The major clinical manifestations were drowsiness, unconsciousness and coma. Of the forty-eight patients, four (8.33%)improved after drug discontinuation, six (12.50%) improved after peritoneal dialysis, and thirty-eight (79.17%) improved after hemodialysis. Conclusion Baclofen can lead to adverse drug reactions in the central nervous system of patients with renal insufficiency. Careful assessment of risk versus benefit is required when baclofen is used for patients with kidney disease. Patients taking baclofen must be monitored.

Key words: baclofen, renal insufficiency, adverse drug reactions