Literature Analysis of Skin Necrosis Induced by Posterior Pituitary Injection

doi:10.19803/j.1672-8629.2020.03.09

Abstract

Abstract: Objective To investigate the common characteristics and regularity of skin necrosis induced by posterior pituitary injection. Methods With " posterior pituitary injection" "skin necrosis", and "adverse drug reaction" as the key words, such databases as CNKI, VIP and WanFang Database were searched. Eighteen articles which met the inclusion and exclusion criteria were selected. Results Skin necrosis caused by posterior pituitary injection mainly occurred in male patients aged 41 to 50, and the primary disease was massive hemorrhage of liver cirrhosis that mostly occurred in lower limbs. The dominating dosages ranged from 20 to 80u per day and skin necrosis was most likely to occur between 3 hours and 2 days. Conclusion Skin necrosis caused by posterior pituitary injection deserves more attention, so clinical drug monitoring has to be strengthened and drug instructions improved.

Key words: posterior pituitary injection, skin necrosis, adverse drug reaction

CLC Number:

R994.11

CHEN Shiwei, XIE Xiaoyan, XIA Xudong, YANG Xue, LIU Cuili. Literature Analysis of Skin Necrosis Induced by Posterior Pituitary Injection[J]. Chinese Journal of Pharmacovigilance, 2020, 17(3): 169-173.

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