Abstract: Objective To investigate the effect of cefoperazone sodium and sulbactam sodium on coagulation function of cerebrovascular patients treated with aspirin and clopidogrel. Methods Sixty patients with ischemic cerebrovascular disease and pneumonia treated in the Department of Neurology were selected as the subjects, who were divided into the control group (treated with piperacillin sodium and tazobactam sodium, n=30) and observation group (treated with cefoperazone sodium and sulbactam sodium, n=30) based on different anti-infective regimens. The activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet count (PLT) were detected to evaluate the effect of cefoperazone sodium and sulbactam sodium on coagulation function. Results The APTT and PT increased significantly (P <0.05) in the two groups after treatment, especially in the observation group. The APTT and PT in the observation group after treatment were longer than in the control group (P <0.01). There was no obvious change in TT or PLT after treatment (P >0.05). Moreover, there was no statistically significant difference in TT or PLT between the two groups. Conclusion Cefoperazone sodium and sulbactam sodium can affect the coagulation function of patients treated with aspirin and clopidogrel, especially the change of APTT and PT. So doctors have to be alert to the risk of bleeding in combined medication.

Key words: cefoperazone sodium and sulbactam sodium, coagulation function, APTT, PT