中国药物警戒 ›› 2014, Vol. 11 ›› Issue (12): 721-724.

• 兰索拉唑与中药联合治疗专栏 • 上一篇    下一篇

兰索拉唑联合中药治疗脾胃湿热型慢性萎缩性胃炎的临床研究

曹志群1, 张晓彤2, 赵庆华2, 李晓宇3, 丁振2, 孙蓉3 *   

  1. 1山东中医药大学附属医院,山东 济南 250011;
    2山东中医药大学,山东 济南 250014;
    3山东省中医药研究院,山东 济南 250014
  • 收稿日期:2014-10-27 修回日期:2016-02-03 出版日期:2014-12-08 发布日期:2016-03-02
  • 通讯作者: 孙蓉,女,博士,研究员·博导,中药药理与毒理。E-mail：sunrong107@163.com
  • 作者简介:曹志群,男,博士,教授·博导,中医内科消化。
  • 基金资助:
    国家自然基金课题：芪莲舒痞颗粒逆转慢性萎缩性胃炎癌前病变机理的研究（30973826）; 国家重大新药创制科技重大专项课题：中药复方药理学研究及药效学评价关键技术（2009ZX09502-015）

Observation of the Curative Effect of Lansoprazole and Herbs in Treating Chronic Atrophic Gastritis of Spleen and Stomach Dampness-heat Syndrome

CAO Zhi-qun1, ZHANG Xiao-tong2, ZHAO Qing-hua2, LI Xiao-yu3, DING Zhen2, SUN Rong3, *   

  1. 1Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Jinan 250011, China; 2Shandong University of Traditional Chinese Medicine, Shandong Jinan 250014, China; 3Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China
  • Received:2014-10-27 Revised:2016-02-03 Online:2014-12-08 Published:2016-03-02

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摘要： 目的探讨兰索拉唑联合中药治疗脾胃湿热型慢性萎缩性胃炎的临床效果。方法将我院92例临床确诊属脾胃湿热型慢性萎缩性胃炎患者,随机分为对照1、2组和联合用药组。对照1组30例采用兰索拉唑进行行治疗;对照2组31例采用中药进行治疗;联合用药组31例采用兰索拉唑联合中药进行治疗,对比观察3组临床疗效。结果联合用药组总有效率为93.6%,对照1组和对照2组总有效率分别为63.3%和74.2%,联合用药组临床治疗效果明显优于对照1、2组,统计学有显著性差异,可明显改善证候,清除HP感染,改善镜下胃黏膜变化。结论兰索拉唑联合中药治疗慢性萎缩性胃炎疗效明显优于单一用药治疗,应加强对联合中药指征、用法、疗程的深入研究,以确保联合用药的合理性和有效性。

关键词: 兰索拉唑, 中药, 脾胃湿热, 慢性萎缩性胃炎

Abstract: ObjectiveTo explore the curative effect of lansoprazole and herbs in treating chronic atrophic gastritis of spleen and stomach dampness-heat syndrome. MethodsNinety-two patients were separated into the treatment group (one group) and the control groups(two groups) randomly, the treatment group took lansoprazole and herbs, the control group 1 took lansoprazole, the control group 2 took herbs. The clinical effects of the three groups were compared. ResultsThe total effective rate of the treatment group was higher than that of the control groups(93.6% vs 63.3% 74.2%, P<0.05), combination therapy can obviously improve the syndromes, eliminate helicobacter pylori infection and improve the changes of gastric mucosa. ConclusionThe clinical effect of lansoprazole combined with herbs in treating atrophic gastritis superior to that of monotherapy, which should strengthen the in-depth study of syndrome, usage, course of treatment of combination therapy, in order to ensure the rationality and effectiveness of the combined use of drugs.

Key words: lansoprazole, herbs, spleen and stomach dampness-heat, chronic atrophic gastritis

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