中国药物警戒 ›› 2014, Vol. 11 ›› Issue (12): 725-728.

• 兰索拉唑与中药联合治疗专栏 • 上一篇    下一篇

兰索拉唑联合中药治疗消化系统疾病的研究现状与理论探讨

王晓妍1, 李晓宇2, 李明   

  • 收稿日期:2014-10-27 修回日期:2016-02-03 出版日期:2014-12-08 发布日期:2016-03-02
  • 通讯作者: 孙蓉,女,博士,研究员·博导,中药药理与毒理研究。E-mail：sunrong107@163.com
  • 作者简介:王晓妍,女,博士,讲师,中医药治疗脾胃病证规律的研究。
  • 基金资助:
    国家重大新药创制科技重大专项课题：中药复方药理学研究及药效学评价关键技术（2009ZX09502-015）,注射用兰索拉唑技术升级及增加临床适应症的研究（2014ZX09201-003-001）

WANG Xiao-yan1 LI Xiao-yu2 LI Ming-jie3 CAO Zhi-qun1 SUN Rong2*

  1. 1Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China;
    2Shandong Academy of Chinese Medicine, Shandong Jinan 250014,China;
    3Shandong Luoxin Pharmacy Stock Co., Ltd., Shandong Linyi 276017, China
  • Received:2014-10-27 Revised:2016-02-03 Online:2014-12-08 Published:2016-03-02

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摘要： 目的 总结兰索拉唑联合中药治疗现状并对相关问题进行思考,为联合治疗前景提供文献支撑。方法 对兰索拉唑联合中药治疗消化性溃疡、胃食管反流病、慢性胃炎的临床研究进行综述。结果 兰索拉唑联合中药可显著提高消化性溃疡、胃食管反流病等与酸分泌相关消化道疾病的临床疗效,有助于缩短病程,降低兰索拉唑不良反应风险。结论 兰索拉唑联合中药前景广阔,但应加强现代治疗学研究,以确保联合治疗用药的合理性和科学性。

关键词: 兰索拉唑, 中药, 联合用药

Abstract: Objective To summarize the current treatments of lansoprazole combined with traditional Chinese medicine (TCM) and think on relevant problems,in order to provide literature supports for future prospects of the combined treatment. Methods This thesis reviewed the clinical studies of lansoprazole combined with TCM in the treatment of peptic ulcer, gastroesophageal reflux disease and chronic gastritis. Results Lansoprazole combined with TCM can significantly improve the clinical efficacy of peptic ulcer, gastroesophageal reflux disease, chronic gastritis and other gastrointestinal diseases related to acid secretion, and help to shorten the course of disease, reduce the risk of adverse reaction of lansoprazole. Conclusion Lansoprazole combined with TCM has broad prospects, but we should strengthen the study of modern treatment, in order to ensure the rationality and scientificity of the united treatment.

Key words: lansoprazole, traditional Chinese medicine, drug combination

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