中国药物警戒 ›› 2024, Vol. 21 ›› Issue (11): 1238-1242.
DOI: 10.19803/j.1672-8629.20240638

• 生殖功能中医药研究专栏 • 上一篇    下一篇

淫羊藿及其主要活性成分改善男性不育症的作用机制研究进展

唐田1,2, 谭天阳3, 刘柘君4, 白雪1,*   

  1. 1中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2中国科学院北京基因组研究所,北京 100101;
    3中国中医科学院西苑医院康复医学科,北京 100091;
    4首都医科大学中医药学院,北京 100069
  • 收稿日期:2024-08-23 出版日期:2024-11-15 发布日期:2024-11-20
  • 通讯作者: *白雪,女,博士,助理研究员,中药防治生殖系统疾病。E-mail: dr.baixue@hotmail.com
  • 作者简介:唐田,女,在读博士,中药对肠道菌群结构和功能作用的研究。
  • 基金资助:
    国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021、ZZ15-YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）; 中国中医科学院西苑医院院级师承项目（YJMPSC202437）

Research Progress of Epimedium in the Treatment of Male Infertility

TANG Tian1,2, TAN Tianyang3, LIU Zhejun4, BAI Xue1,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing 100101, China;
    3Rehabilitation Medicine Department, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China;
    4School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • Received:2024-08-23 Online:2024-11-15 Published:2024-11-20

PDF (PC)

71

摘要： 目的 评估淫羊藿及其主要活性成分在治疗男性不育症中的潜力,探讨其在中医药治疗中的应用前景。方法 通过系统文献回顾,分析淫羊藿及其主要活性成分在改善精子生成、保护睾丸微环境、调节性激素水平、抗氧化应激及改善性功能障碍等方面的作用。结果 淫羊藿及其主要活性成分显示出通过调节关键信号通路和改善细胞凋亡来保护生殖细胞的潜力,同时在改善性功能障碍方面也显示出积极效果。结论 淫羊藿的活性成分在治疗男性不育症方面具一定的潜力,未来研究应进一步验证其临床疗效,以促进其在男性生殖健康领域的应用。

关键词: 男性不育, 淫羊藿, 活性成分, 机制, 生殖, 精子生成, 抗氧化应激

Abstract: Objective To assess the potential of Epimedium and its active components in the treatment of male infertility and to explore their prospects in traditional Chinese medicine therapy. Methods A systematic literature review was conducted to analyze the significant effects of Epimedium and its main active components on improving spermatogenesis, protecting the testicular microenvironment, regulating sex hormone levels, combating oxidative stress, and alleviating sexual dysfunction. Results Epimedium demonstrated the potential to protect germ cells by modulating key signaling pathways and improving apoptosis, and it also showed positive effects in improving sexual dysfunction. Conclusion The active components of Epimedium have significant potential in the treatment of male infertility. Future research should further verify their clinical efficacy to promote their application in the field of male reproductive health.

Key words: Male Infertility, Epimedium, Active Ingredients, Mechanism, Reproductive, Spermogenesis, Antioxidant Stress

中图分类号: