肝硬化动物模型的研究进展与中药药效评价思考

中国药物警戒 ›› 2016, Vol. 13 ›› Issue (1): 32-35.

肝硬化动物模型的研究进展与中药药效评价思考

石亮^1,2,孙蓉¹

1.山东省中医药研究院 ,山东济南 250014;
2.山东中医药大学 ,山东济南 250355

收稿日期:2015-10-15 修回日期:2016-02-25 出版日期:2016-01-08 发布日期:2016-02-25
通讯作者: 孙蓉,女,博士,研究员·博导,中药药理与毒理。
作者简介:石亮, 男, 在读硕士, 中药药理学。
基金资助:
国家自然科学基金面上项目(81374059); 山东省自主创新和成果转化项目(2014ZZCX02104)。

Advances in Establishment of Animal Models with Hepatic Cirrhosis and Thinking about Efficacy Evaluation of Traditional Chinese Medicine

SHI Liang^1,2, SUN Rong¹

1.Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China;
2.Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China

Received:2015-10-15 Revised:2016-02-25 Online:2016-01-08 Published:2016-02-25

摘要/Abstract

摘要： 目的介绍近年来肝硬化动物模型的研究进展并进行中药药效评价思考。方法对近十几年来国内外相关文献对肝硬化动物模型的报道进行整理、分析和归纳。结果目前主要有两大类建模方案单因素诱导建模及复合因素诱导建模。结论实验中应该根据中药自身的特点来选择合适的动物模型 ,进行候选药物的筛选和药效评价 ,并能够将肝硬化动物模型的研究与临床疾病的研究紧密地结合起来 ,为临床前的中药药理研究和药效评价提供方法学保证。

关键词: 肝硬化, 动物模型, 研究进展

Abstract: Objective To introduce the research development on the advances in establishment of animal models with hepatic cirrhosis and think about efficacy evaluation of traditional Chinese medicine (TCM). Methods The related references in the last decades at home and abroad about cirrhosis model were collated, analyzed and summarized. Results At present, single factor induced modeling and composite factors induced modeling were mainly two categories of the modeling scheme. Conclusion We should choose suitable animal model on the basis of TCM’s characteristic and combine the research of cirrhosis model with clinical disease closely, in order to screen and evaluate candidate drug, and offer methodological ensurance for TCM’s pharmacological preclinical research and efficacy evaluation at the same time.

Key words: hepatic cirrhosis, animal model, research progress

中图分类号:

R965

石亮,孙蓉. 肝硬化动物模型的研究进展与中药药效评价思考[J]. 中国药物警戒, 2016, 13(1): 32-35.

SHI Liang,SUN Rong. Advances in Establishment of Animal Models with Hepatic Cirrhosis and Thinking about Efficacy Evaluation of Traditional Chinese Medicine [J]. Chinese Journal of Pharmacovigilance, 2016, 13(1): 32-35.

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