变应性鼻炎相关动物模型研究进展

doi:10.19803/j.1672-8629.20230654

摘要/Abstract

摘要： 目的综述变应性鼻炎（allergic rhinitis, AR）相关动物模型的研究进展,为深入研究AR的发病机制及药物评价提供参考。方法通过对国内外文献的查阅,从AR模型动物的种类、特点、模型种类、建模方法、模型成功的标准和评价指标等方面进行总结。结果变应性鼻炎相关动物模型包括西医病理模型和中医病症结合模型,动物选择多使用豚鼠、小鼠、大鼠、新西兰兔等。结论总结已有AR动物模型的种类、方法和评价指标以及在AR发病机制研究中的应用,可为后续AR的深入研究提供参考。

关键词: 变应性鼻炎, 动物模型, 机制, 评价指标, 豚鼠, 小鼠, 大鼠, 新西兰兔

Abstract: Objective To summarize the research progress on animal models related to allergic rhinitis (AR), providing a reference for further understanding of AR pathogenesis and drug evaluation. Methods Based on a literature review from both domestic and international sources, the types of AR animal models, their characteristics, modeling methods, criteria for successful models, and evaluation indicators were summarized. Results Animal models for allergic rhinitis include both Western medicine pathological models and traditional Chinese medicine combination models. Commonly used animals include guinea pigs, mice, rats, and New Zealand rabbits. Conclusion This review provides insights into existing AR animal models, their methods, and evaluation criteria, offering valuable guidance for future AR research.

Key words: allergic rhinitis, animal model, mechanism, evaluation indicators, Guinea pigs, mice, rats, New Zealand rabbits

中图分类号:

R994.1

孙绮悦, 郭姗姗, 赵荣华, 包蕾, 耿子涵, 李舒冉, 徐英莉, 张敬升, 崔晓兰, 孙静. 变应性鼻炎相关动物模型研究进展[J]. 中国药物警戒, 2024, 21(3): 241-245.

SUN Qiyue, GUO Shanshan, ZHAO Ronghua, BAO Lei, GENG Zihan, LI Shuran, XU Yingli, ZHANG Jingsheng, CUI Xiaolan, SUN Jing. Research progress on animal models of allergic rhinitis[J]. Chinese Journal of Pharmacovigilance, 2024, 21(3): 241-245.

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