中国药物警戒 ›› 2023, Vol. 20 ›› Issue (10): 1189-1194.
DOI: 10.19803/j.1672-8629.20230120

• 综述 • 上一篇    下一篇

高原气虚血瘀证动物模型评价及治疗药物研究进展

高敬1,2, 张卓2, 闫佳怡2,3, 葛运炫2,4, 马增春2, 高月2,*   

  1. 1河南大学药学院,河南 开封 475004;
    2军事医学研究院军事医学研究所辐射医学研究所,北京 100850;
    3天津中医药大学药学院,天津 301617;
    4北京工业大学环境与生命学部,北京 100124
  • 收稿日期:2023-03-09 出版日期:2023-10-15 发布日期:2023-10-16
  • 通讯作者: *高月,女,研究员,中药药理与毒理学。E-mail: gaoyue@bmi.ac.cn
  • 作者简介:高敬,女,在读硕士,中药学。
  • 基金资助:
    国家重点研发计划（2022YFC3500303）; 全军后勤科研项目（BLJ20J011）; 国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-D-202207）; 中医药传承创新团队（ZYYCXTD-C-202009）

Evaluation of animal models of high altitude qi deficiency and blood stasis syndrome and research progress in therapeutic drugs

GAO Jing1,2, ZHANG Zhuo2, YAN Jiayi2,3, GE Yunxuan2,4, MA Zengchun2, GAO Yue2,*   

  1. 1College of Pharmacy, Henan University, Kaifeng Henan 475004, China;
    2Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;
    3School of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;
    4Faculty of Environment and Life Science, Beijing University of Technology, Beijing 100124, China
  • Received:2023-03-09 Online:2023-10-15 Published:2023-10-16

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摘要： 目的 总结归纳近年高原气虚血瘀证动物模型制备和治疗药物相关研究,为进一步规范高原气虚血瘀证动物模型研究和治疗药物的研发提供参考。方法 检索近20年中国知网、万方数据、维普网中已发表的高原气虚血瘀证动物模型制备和治疗药物文献,对其进行归纳总结。结果 目前高原气虚血瘀证动物模型多采用低压低氧寒冷的复合方式制备,存在很多缺陷,如现代医学及病理学的模型制备方式不符合中医理论的病因病机学说发展规律,缺乏客观、量化、规范的中医药宏观表征评价指标,中医特色的四诊合参和辨证论治没有全面体现等,其治疗方案多借鉴气虚血瘀证治疗组方,或对经典名方进行加减放用来治疗高原气虚血瘀,同时缺乏反证方剂。结论 高原气虚血瘀证相关性研究较少,需要统一其动物模型制备方法,完善其诊断和评价体系,开发能够评价其治疗药物的反证方剂。同时,期望能够推动以高原气虚血瘀证为基础的高原病及其药物研发的进展。

关键词: 高原, 气虚血瘀证, 动物模型, 药物评价, 药物研究, 高原病, 病因学, 病机学

Abstract: Objective To summarize the ways animal models of high altitude qi deficiency and blood stasis syndrome have been established in recent years and different studies on related therapeutic drugs so as to provide reference for standardization of studies on animal models of high altitude qi deficiency and blood stasis syndrome and the research and development of therapeutic drugs. Methods Literature on establishment of animal models and therapeutic drugs of high altitude qi deficiency and blood stasis syndrome published in CNKI, Wanfang and VIP database in the past 20 years was searched for and summarized. Results The animal models of high altitude qi deficiency and blood stasis syndrome were mostly prepared via the combination of low pressure, low oxygen and cold, which left much to be desired. For example, the methods for establishing these models using modern medicine and pathology did not conform to TCM theories on etiology and pathogenesis, lacked objective, quantitative and standardized evaluation indexes of TCM for macro symptoms, and failed to reflect the combined use of the four diagnostic methods of TCM. The related treatment plans mostly worked by referring to the prescriptions for treating qi deficiency and blood stasis syndrome, or by revising classic well-known prescriptions to treat qi deficiency and blood stasis at a high altitude, without enough counter-evidence prescriptions. Conclusion There are relatively few studies on high altitude qi deficiency and blood stasis syndrome, so there is the need to make uniform methods for establishing the animal models, improve the diagnosis and evaluation system, and develop counter-evidence prescriptions. At the same time, it is hoped that the development of altitude disease and the research and development of drugs can be promoted based on the syndrome of altitude qi deficiency and blood stasis.

Key words: high altitude, qi deficiency and blood stasis syndrome, animal model, drug evaluation, drug studies, altitude disease, etiology, pathogenesis

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