关键词: 双环醇, 阿霉素, 环磷酰胺, 抗肿瘤, 小鼠

Abstract: ObjectiveTo investigate the effect of bicyclol and combinative effect of bicyclol with anti-tumor drugs on survival condition of tumor-bearing mice. MethodsKunming mice transplanted with S180 sarcoma were administrated with 200 mg·kg^-1 bicyclol for 7 days, and simultaneously injected with 8 mg·kg^-1 adriamycin or 70 mg·kg^-1 cyclophosphamide at the first day and sixth day. After treatment, six mice of each group were sacrificed and the inhibitory rate of tumor growth was calculated. Animal death in the remaining animals was recorded. C57BL/6 mice were administrated with 150 mg·kg^-1 bicyclol for 14 days after 9 days transplanted with Lewis lung carcinoma. C57BL/6 mice were treated with bicyclol(50 mg·kg^-1,100 mg·kg^-1) for 18 days after 5 days transplanted with B16-F10 melanoma carcinoma. In these two models, the body weight and survival condition of mice were observed. ResultsIn S180 sarcoma and B16-F10 melanoma tumor-bearing mice models, bicyclol significantly prolonged the median survival time and decreased the mortality rate of tumor-bearing mice. However, there was no marked improvement effect at mice survival rate in C57BL/6 Lewis lung tumor-bearing mice models with bicyclol treatment. The combination of bicyclol with anti-

Key words: bicyclol, adriamycincyclophosphamide, anti-tumor, mice