基于功效和物质基础的补骨脂毒性研究进展

中国药物警戒 ›› 2014, Vol. 11 ›› Issue (8): 482-484.

基于功效和物质基础的补骨脂毒性研究进展

赵庆华, 孙蓉^1*

1山东省中医药研究院,山东济南 250014;
2山东中医药大学,山东济南 250355

收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-08-08 发布日期:2016-03-02
通讯作者: 孙蓉,女,研究员·博导,博士,中药药理与毒理。E-mail：sunrong107@163.com
作者简介:赵庆华,女,在读硕士,中药药理与毒理研究。
基金资助:
基金项目：国家重点基础研究发展计划（973）中医基础理论专项资助项目课题2（2009CB522802）; 山东省中医药现代化专项平台建设类课题：基于中医药理论和国际化的中药肝毒性评价技术平台建立（2008GG2NS02021）

Research Development on Toxicity of Psoralea corylifolia L. Related to Efficacy and Chemical Material Basis

ZHAO Qing-hua^{1, 2}, SUN Rong^{1, *}

1Shandong Research Academy of TCM, Shandong Jinan 250014, China;
2Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China

Received:2016-02-03 Revised:2016-02-03 Online:2014-08-08 Published:2016-03-02

摘要/Abstract

摘要： 目的为明确补骨脂的功效和毒性物质基础、功效和毒性的相关性以及为今后安全标准制订和进行功效物质基础下补骨脂的毒性研究提供文献依据和研究思路。方法对文献古籍中对补骨脂毒性的记载及近十几年来补骨脂国内外相关文献报道进行整理、分析与归纳。结果历代古籍对补骨脂毒性记载甚少,现代研究仅局限于补骨脂药理、毒理、化学成分等独立性研究,缺少其功效、毒性、物质基础三者关联性研究。因此,应依托功效和物质基础,制订完善的补骨脂安全使用标准,使其毒性可被科学控制。结论只有在补骨脂功效表达和功效物质基础分离与控制的过程中,进行毒性的研究和毒性物质基础的安全控制,才能提出切合补骨脂临床使用过程中药品不良反应的预警方案和早期诊疗措施,确保补骨脂临床用药安全。

关键词: 补骨脂, 功效, 物质基础, 毒性

Abstract: ObjectiveTo provide literature evidence and research ideas for determining the correlation of efficacious and toxic substance basis as well as the correlation of its efficacy and toxicity of Psoralea corylifolia, making safety standards, and studying its toxicity based on its efficacious substance basis. MethodsReferences in old days and last decades at home and abroad about Psoralea corylifolia were collated, analyzed and summarized. ResultsThe references in old days were lacking in the records of toxicity of Psoralea corylifolia. The recent researches were confined to the isolated aspect such as pharmacology, toxicology, chemical constituents and lacked the correlations of efficacy, toxicity and material basis. Consequently, blameless safely using standards should be made based on efficacy and material basis, and insure that its toxicity could be scientifically controlled. ConclusionOnly study Psoralea corylifolia's toxicity and control safely the toxic material basis during the expression of effectiveness and the separation and quality controlling of efficacious material basis, could we put forward early-warning scheme and treatment measures of adverse reaction in clinical usage, so as to ensure the safe use of Psoralea corylifolia as a clinical drug.

Key words: Psoralea corylifolia L., efficacy, material basis, toxicity

中图分类号:

R282.71

赵庆华, 孙蓉. 基于功效和物质基础的补骨脂毒性研究进展[J]. 中国药物警戒, 2014, 11(8): 482-484.

ZHAO Qing-hua, SUN Rong. Research Development on Toxicity of Psoralea corylifolia L. Related to Efficacy and Chemical Material Basis[J]. Chinese Journal of Pharmacovigilance, 2014, 11(8): 482-484.

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