孕期对乙酰氨基酚暴露致发育毒性及其机制研究进展

doi:10.19803/j.1672-8629.20240815

摘要/Abstract

摘要： 目的探讨对孕期乙酰氨基酚（APAP）暴露的发育毒性及其可能机制,为临床安全合理用药提供参考。方法结合最新文献研究,针对孕期母亲使用APAP与子代宫内生长迟缓、发育畸形及功能障碍,出生后至成年期罹患神经系统、泌尿生殖系统和呼吸免疫系统等疾病的关系及影响进行论述。结果孕期母亲服用APAP与胎儿先天性畸形、不良围产结局和神经发育异常等多种发育毒性存在相关性,其发育毒性的可能机制有APAP及其代谢产物的酶抑制作用、代谢与氧化损伤、内分泌干扰作用和表观遗传修饰异常等。结论孕期应合理使用APAP,以保障母胎健康,提高临床安全用药。

关键词: 对乙酰氨基酚, 发育毒性, 注意缺陷多动障碍, 自闭症谱系障碍

Abstract: Objective To investigate the developmental toxicity of prenatal acetaminophen (APAP) exposure and the potential mechanisms in order to provide references for safe clinical medication. Methods The associations between the use of APAP during pregnancy and such developmental outcomes as intrauterine growth restriction, developmental malformations and functional impairments in offspring, and between APAP and postnatal and adult-onset diseases involving the nervous system, urogenital system, respiratory system and immune system were discussed based on the latest literature. Results Medications with APAP during pregnancy might cause intrauterine fetal growth retardation, developmental malformations, organ dysfunctions, and increased susceptibility to neurological, genitourinary, and respiratory diseases in adult offspring. The potential mechanisms underlying developmental toxicity included cyclooxygenase inhibition, oxidative damage, endocrine disruption, and epigenetic dysregulation. Conclusion The rational use of APAP during pregnancy is crucial to maternal and fetal health.

Key words: Acetaminophen (APAP), Developmental Toxicity, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder

中图分类号:

R971
R994.11

梅昊楠, 张子依, 王昱希, 汪晖, 郭喻. 孕期对乙酰氨基酚暴露致发育毒性及其机制研究进展[J]. 中国药物警戒, 2025, 22(6): 702-707.

MEI Haonan, ZHANG Ziyi, WANG Yuxi, WANG Hui, GUO Yu. Developmental Toxicity and Mechanisms of Acetaminophen Exposure during Pregnancy[J]. Chinese Journal of Pharmacovigilance, 2025, 22(6): 702-707.

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